Relation of Cardiac Dysfunction to Thyroid Stimulating Hormone in Children with Down Syndrome

Authors: Mohamed E. Mowafy, Omneya I. Youssef and Heba S. Abd Elkhalek

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Keywords: Cardiac abnormalities, thyroid dysfunctions, Down syndrome.


Background: Down syndrome (DS) is the most common autosomal chromosomal anomaly. It may be associated with congenital heart disease (CHD) and various thyroid  abnormalities.

Objective: To evaluate cardiac functions in relation to the thyroid profile in patients with DS.

Subjects and Methods: 100 consecutive patients with DS recruited from genetics clinic were enrolled, their ages ranged from 9 to 264 months. Free T4, TSH levels and thyroid antibodies (anti-thyroglobulin and anti-peroxidase) were measured, M mode, 2D, colour pulsed, continuous wave Doppler and tissue Doppler echocardiography were done.

Results: Subclinical hypothyroidism was detected in 8% of DS patients. 59 % of patients had left ventricular (LV) diastolic dysfunction and 18% had right ventricle (RV) diastolic dysfunction. There was statistically significant difference between patients with and without LV diastolic dysfunction regarding TSH. There was a significant positive correlation between TSH level and E wave at tricuspid annulus 

Conclusion: Subclinical hypothyroidism was found in 8% of our DS patients, 59 % of patients had LV diastolic dysfunction and 18% had RV diastolic dysfunction.

Key words: Cardiac abnormalities, thyroid dysfunctions, Down syndrome.