Relation of Cardiac Dysfunction to Thyroid Stimulating Hormone in Children with Down Syndrome
Authors: Mohamed E. Mowafy, Omneya I. Youssef and Heba S. Abd Elkhalek
Background: Down syndrome (DS) is the most common autosomal chromosomal anomaly. It may be associated with congenital heart disease (CHD) and various thyroid abnormalities.
Objective: To evaluate cardiac functions in relation to the thyroid profile in patients with DS.
Subjects and Methods: 100 consecutive patients with DS recruited from genetics clinic were enrolled, their ages ranged from 9 to 264 months. Free T4, TSH levels and thyroid antibodies (anti-thyroglobulin and anti-peroxidase) were measured, M mode, 2D, colour pulsed, continuous wave Doppler and tissue Doppler echocardiography were done.
Results: Subclinical hypothyroidism was detected in 8% of DS patients. 59 % of patients had left ventricular (LV) diastolic dysfunction and 18% had right ventricle (RV) diastolic dysfunction. There was statistically significant difference between patients with and without LV diastolic dysfunction regarding TSH. There was a significant positive correlation between TSH level and E wave at tricuspid annulus
Conclusion: Subclinical hypothyroidism was found in 8% of our DS patients, 59 % of patients had LV diastolic dysfunction and 18% had RV diastolic dysfunction.
Key words: Cardiac abnormalities, thyroid dysfunctions, Down syndrome.