Obesity and Hyperlipidemia in Survivors of Childhood Acute Lymphoblastic Leukemia
Background: Cure rates of childhood leukemia have improved significantly during the past few decades, and with this improving survivorship, long-term treatment related effects are being observed more frequently and need to be assessed. Survivors are at increased risk for obesity, insulin resistance, and increased visceral and subcutaneous adiposity.
Objective: to assess prevalence of obesity in survivors of childhood ALL and to Identify risk factors for obesity among this group of patients.
Results Obesity and overweightness were more prevalent among ALL survivors than control group (32% and 13.3 respectively) (P = 0.025). Waist and hip circumference were significantly higher in the survivors (P <0.0001), however, no difference in waist: hip ration was found between both groups. ALL survivors had significantly higher level of serum total cholesterol (P = 0.03) but comparable results of LDL-C, HDL-C and triglycerides.
Conclusion: ALL survivors are more prone to obesity which may increase their future risk of developing metabolic syndrome. Incorporating preventive strategies into the treatment regimen may be needed to prevent early development of these metabolic abnormalities.