The Relation between Serum Zinc Level and Iron Profile to Community Acquired Pneumonia in Pediatrics

Authers: Asmaa A. Ahmed, Ahmed R, Ahmed, Noha R. Mohamed, and Tasneem A. E. Mogahed

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Keywords: Community acquired pneumonia, serum iron level, TIBC, serum zinc, children.


Background: Community-acquired pneumonia (CAP) is the most severe form of acute respiratory infections accounting for 80% of all deaths from acute respiratory infections and 20% of all deaths in children. Inadequate nutrition and acute lower respiratory infection (ALRI) are overlapping and interrelated health problems affecting children in developing countries.

Objective: To assess the relation between serum zinc and iron profile to community acquired pneumonia as regard; occurrence, short term morbidity and mortality.

Subjects and methods: The study was conducted at outpatient clinic and emergency room, children's hospital, Ain Shams University. Sixty seven patients were selected: 31 with community acquired pneumonia and 36 apparently healthy (control group), their age were from 2 months to 54months. Serum zinc, TIBC and serum iron were measured using ELISA.

Results: Mean values of serum zinc level was significantly lower in patients than control group (114.29 ± 45.01 μg/dl versus 145.01 ± 64.69 μg/dl) (p 0.030). Mean values of serum iron level was lower – but not significant- among patients than control (127.54 ± 31.68μg/dl versus 138.17 ± 40.39μg/dl). Mean values of serum TIBC level was significantly lower among patients than control (580.05 ± 126.68μg/dl versus (519.69 ± 109.43μg/dl) (p 0.040). Zinc deficiency didn’t affect pneumonia severity or patient final outcome.

Conclusion: adequate serum zinc may be protective against infection with community acquired pneumonia in children aged from 2 months to 5 years old and patient with CAP may have disturbed iron profile like high TIBC but there is no relation between adequate serum iron level and community acquired pneumonia affecting the same age group.